A systematic genome-wide association analysis for inflammatory bowel diseases (IBD)

Franke, Andre

Two independent and hypothesis-free genome-wide association studies were carried out to find novel susceptibility genes for Crohn’s disease (CD), which is a chronic inflammatory disorder of the bowel. In a first sequence-based and “direct” scan, approximately 20,000 nonsynonymous SNPs, which result in a change in protein sequence, were typed. The second “indirect” map-based scan comprised about 100,000 evenly distributed SNPs.

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Franke, Andre: A systematic genome-wide association analysis for inflammatory bowel diseases (IBD). 2006.

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