Design of Photoswitchable Contrast Agents for Magnetic Resonance Imaging
Magnetically switchable nickel(II)porphyrins were designed, prepared and investigated in view of their application as switchable contrast agents for magnetic resonance imaging (MRI). The results are very promissing. The magnetic switching performance of the applied photochromic nickel(II)porphyrins was investigated and could be drastically improved. Reversible photoswitching of MRI contrasts was achieved with organic solvents. Furthermore two approaches regarding an in vivo application were presented. The first aims at the nickel(II) spin state switching in water. The second aims at a spin switching by irradiation with near infrared light.