Towards a glycobiological toolbox for the investigation of bacterial adhesion
Bacterial adhesion of pathogenic Escherichia coli triggers many diseases such as neonatal meningitis, gastroenteritis and urinary tract infections. The first initial adhesion step is mediated by carbohydrate specific lectins located at the tip of bacterial fimbriae. In uropathogenic E. coli the most common ones are type 1 and P fimbriae. Research interest is focused on the design and testing of new inhibitors against both of the lectins FimH and PapG. Additional to new inhibitors it is crucial to get a better understanding of the binding mechanism between lectins and carbohydrate as well as the influence of exterior ascendancies. Therefore three main topics were addressed: bacterial adhesion studies, examination of shear force influence and glyconanoparticles.