Structural analysis of carbohydrate – protein interactions under special consideration of lipopolysaccharide fragments, hyaluronic acid, sulfated polysaccharides and sialic acids
Carbohydrate – protein interactions play very important roles in many biological functions. For example, cell-cell recognition, cell adhesion, signal transduction, fertilization, infection and inflammation etc. The better understanding of these binding activities could help to develop more cutting-edge treatment strategies. With the progress of science and technology, more and more new structural analyses of carbohydrate-protein interactions are published. Within this thesis, the focus was on analyzing carbohydrate – protein interactions under special consideration of LPS fragments, hyaluronic acid, sulfated saccharides and sialic acids, with biophysical (NMR, X-ray, SPR), biochemical and cell-biological methods.
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