Proteolytic control of necroptosis
The present works’ aim has been to gain further insights into the proteolytic mechanisms present in necroptosis via multiple routes: investigating an in-vivo model for necroptosis in DSS-induced colitis in mice with an extremely reduced expression of the sheddase ADAM17, investigating the role of the phosphoglycerate mutase family member 5 (PGAM5) in necroptosis, analysis of the function of the protease HtrA2/Omi and its possible substrates in
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