Epigenome and chromosome dynamics in the fungal pathogen Zymoseptoria tritici

Fungal genomes exhibit extraordinary intra- and interspecies diversity. Although advances in population genetic studies highlight genome variability, little is known about the underlying mechanisms driving this diversification. The main focus of this thesis is to elucidate dynamics and mechanisms of genome stability and chromosome loss in the fungal plant pathogen Zymoseptoria tritici. Taken together, we demonstrate that epigenetic regulation in form of histone modification is a crucial component of genome stability in Z. tritici that likely contributes to the high genomic diversity in natural populations.


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