Dissertation (Metadaten)
Titel:A systematic genome-wide association analysis for inflammatory bowel diseases (IBD)
Autor:Andre Franke
Fakultät:Mathematisch-Naturwissenschaftliche Fakultät
DDC Sachgebiet:570 Biowissenschaften, Biologie
Datum der mdl. Prüfung:08.11.2006
Referent(in):Prof. Dr. Dr. T.C.G. Bosch
Korreferent(en) Korreferentin:Prof. Dr. S. Schreiber
Beschreibung:Two independent and hypothesis-free genome-wide association studies were carried out to find novel susceptibility genes for Crohn’s disease (CD), which is a chronic inflammatory disorder of the bowel. In a first sequence-based and “direct” scan, approximately 20,000 nonsynonymous SNPs, which result in a change in protein sequence, were typed. The second “indirect” map-based scan comprised about 100,000 evenly distributed SNPs.
Schlagworte:Inflammatory Bowel Diseases, Crohn's disease, association study, Linkage disequilibrium, autophagy, ATG16L1, CARD15, genome-wide,
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