Synthesis of functional glycoconjugates to explore structural aspects of carbohydrate recognition

Cell surface glycoconjugates play an important role in many fundamental processes of cell recognition. For example, bacterial adhesion is mediated by carbohydrate-specific binding of bacterial lectins to the glycocalyx of host cells. The molecular and structural complexity of the glycocalyx is essential for its biological function but yet has not been understood in every detail. Thus, scientists are interested in developing new tools and methods to investigate the role of glycans in biological processes. Within the scope of this thesis multifunctional glycoconjugates were designed and synthesized to study in particular, the organization of multivalency and the conformational switching of monosaccharides in the context of carbohydrate recognition.



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