Immune cell profiling reveals natural killer and T cell subpopulations to be associated with atopic dermatitis severity
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a genetically determined impaired epidermal barrier function and predisposition to develop other atopic comorbidities.The role of adaptive and innate immunity, in particular IL- 4 and IL- 13 and T lymphocyte populations in AD pathogenesis are established, but the exact cellular mechanisms are not fully understood. At least
partially, this is attributed to technical limitations of flow cytometry, that is, limited channels and signal spillover. Mass cytometry overcomes these limitations and allows advanced bioinformatic methods. An unbiased comprehensive analysis of the total peripheral immune cell pool in AD is not available.
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