Immune cell profiling reveals natural killer and T cell subpopulations to be associated with atopic dermatitis severity

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized  by  a  genetically  determined  impaired  epidermal  barrier function and predisposition to develop other atopic comorbidities.The role of adaptive and innate immunity, in particular IL- 4 and IL- 13 and T lymphocyte populations in AD pathogenesis are established, but the exact cellular mechanisms are not fully understood. At least
partially, this is attributed to technical limitations of flow cytometry, that is, limited channels and signal spillover. Mass cytometry overcomes  these  limitations  and  allows  advanced  bioinformatic  methods.  An  unbiased  comprehensive  analysis  of  the  total  peripheral immune cell pool in AD is not available.

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