Rekrutierung von Natürlichen Killerzellen durch optimierte Immunliganden

NK cells emerged as promising immune cells for cancer therapy. Beyond antibody-based approaches triggering NK cell activity via the FcγRIIIa, also multifunctional approaches are being exploited to redirect NK cell cytotoxicity against malignant cells. In this respect, immunoligands which are fusion proteins composed of an antibody-derived targeting arm and a natural ligand for an activating receptor on NK cells show great promise in inducing effector cell activation against tumor cells.


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