Vitamin C and Vitamin D-friends or foes in modulating γδ T-cell differentiation?

The differentiation and functional plasticity of T cells are transcriptionally and epigenetically regulated by signals imposed by the local cytokine milieu and a variety of additional factors, including vitamins. Vitamin C has pleiotropic functions in the
immune system. It exerts antioxidant activity, can directly kill selected tumor targets, promotes early T-cell differentiation, and enhances Th1 cytokine production in mature T cells.

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Additional data

Published in:
Cellular & molecular immunology
Publisher:
Springer Science and Business Media LLC
Chinese Society of Immunology
Publishing place:
London [u.a.]
Beijing
Vol.:
19
No.:
10
ISSN:
1672-7681
ISSN:
2042-0226
Pages:
1198 - 1200
Date Issued:
2022
URN:
urn:nbn:de:gbv:8:3-2024-00387-4
DOI:
10.1038/s41423-022-00895-w
Other identifier (pubmed):
35799058
Language:
English
Type of Resource:
Text
Publisher:
Springer Science and Business Media LLC
Keywords:
T-Lymphocyte Subsets; Humans; Ascorbic Acid; Vitamin D; Receptors; Antigen; T-Cell; gamma-delta; Lymphocyte Activation; Cell Differentiation
Classification:
Published version
DDC subject of DNB:
610 Medical sciences, health
Hosting institution:
Faculties, Faculty of Medicine
Hosting institution:
Affiliated Institutes, University Hospital Schleswig-Holstein (UKSH)

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