Frequency and prognostic implications of KMT2A rearrangements in children with precursor B-cell lymphoma

Our analysis is limited regarding to the molecular features of BCP-L, since pediatric BCP-L is rare compared to BCP-ALL, and we were limited to archival BCP-L tissue that were small and preserved in FFPE blocks. Nevertheless, our data suggest that BCP-L is a valuable model for studying pathogenic mechanisms of BCP neoplasms, especially those with KMT2A aberrations. Detailed molecular genetic analysis will be required to understand which mechanisms lead to the clinical presentation as lymphoma instead of leukemia, and whether this clinical presentation is driven by genetic features of the tumor, or host dependent factors such as immunological status.

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