Isoflurane vs. propofol for sedation in invasively ventilated patients with acute hypoxemic respiratory failure: an a priori hypothesis substudy of a randomized controlled trial

Background

Acute hypoxemic respiratory failure (AHRF) is a leading concern in critically ill patients. Experimental and clinical data suggest that early sedation with volatile anesthestics may improve arterial oxygenation and reduce the plasma and alveolar levels of markers of alveolar epithelial injury and of proinflammatory cytokines.

Conclusions

In patients with AHRF, inhaled sedation with isoflurane for a duration of up to 48 h did not lead to improved oxygenation in comparison to intravenous sedation with propofol. Trial registration The main study was registered in the European Medicines Agency's EU Clinical Trial register (EudraCT), 2016-004551-67, before including the first patient. The present substudy was registered at German Clinical Trials Register (DRKS, ID: DRKS00018959) on January 7th, 2020, before opening the main study data base and obtaining access to study results.

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Additional data

Published in:
Annals of intensive care
Publisher:
Springer Science and Business Media LLC
Publishing place:
Heidelberg
Vol.:
12
No.:
1
ISSN:
2110-5820
Date Issued:
2022
URN:
urn:nbn:de:gbv:8:3-2024-00445-8
DOI:
10.1186/s13613-022-01090-w
Other identifier (pubmed):
36538243
Language:
English
Type of Resource:
Text
Publisher:
Springer Science and Business Media LLC
Keywords:
Propofol; Acute respiratory distress syndrome; Isoflurane; Acute Hypoxemic Respiratory Failure; Ventilator-induced Lung Injury; Inhalation Sedation
Classification:
Published version
DDC subject of DNB:
610 Medical sciences, health
Hosting institution:
Faculties, Faculty of Medicine
Hosting institution:
Affiliated Institutes, University Hospital Schleswig-Holstein (UKSH)

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