The role of B4galnt2 in shaping the outcome of antibiotic treatment and susceptibility to enteric pathogens
The gut microbiota, comprising of a diverse group of bacteria and other microorganisms, plays important roles in nutrient metabolism, immune system development, and protection against pathogens. The B4galnt2 gene, which exhibits a tissue-specific expression pattern in mice, influences the composition and function of these microbial communities, which in turn affects the host's susceptibility to infections like Salmonella Typhimurium. This thesis examines the influence of B4galnt2 expression on the dynamics of the gut microbiota, with a particular focus on the effects of antibiotic treatment and infection by intestinal pathogens. The study employs a shotgun metagenomic sequencing approach to analyze taxonomic and functional profiles of gut associated microbial communities.
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