Crohn's-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d

In  the  recent  study  by  Rosati  et  al,  we described  a  novel  unconventional  T  cell population  enriched  in  the  peripheral blood of patients with Crohn’s disease (CD) and  characterised  by  a  semi- invariant  Tcell receptor (TCR) repertoire. 1  However, the specificity of these Crohn’s- associated invariant T (CAIT) cells was not defined.
Identifying the specificity of CAIT cells is essential  to  understand  the  origin  of  the antigen triggering their enrichment in CD.

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Published in:
Gut : the journal of the British Society of Gastroenterology ; an international journal of gastroenterology and hepatology / ed. Sheila Sherlock
Publisher:
BMJ
British Medical Assoc.
Publishing place:
London
London
Vol.:
73
No.:
1
ISSN:
0017-5749
ISSN:
1468-3288
Pages:
205 - 206
Date Issued:
2023
URN:
urn:nbn:de:gbv:8:3-2024-00969-8
DOI:
10.1136/gutjnl-2022-328684
Other identifier (pubmed):
36428091
Language:
English
Type of Resource:
Text
Publisher:
BMJ
Keywords:
T-Lymphocytes; Humans; Colitis, Ulcerative; Crohn Disease; T lymphocytes; T-cell receptor; Crohn's Disease
Classification:
Published version
DDC subject of DNB:
610 Medical sciences, health
Hosting institution:
Faculties, Faculty of Mathematics and Natural Sciences
Hosting institution:
Faculties, Faculty of Medicine
Hosting institution:
Affiliated Institutes, University Hospital Schleswig-Holstein (UKSH)

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