In vitro investigation on the regenerative effect of Magnesium-based microparticles for osteoarthritis treatment

Osteoarthritis (OA) is one of the degenerative and epidemic joint disorders occurring worldwide. Although the molecular mechanisms are poorly understood, aging, gender, heredity, joint injury, impaired joint movement, stress and obesity are the main OA etiology.  Till now there are no benchmark medical therapies for preventing or delaying OA onset. This thesis investigates the possibility of using Magnesium (Mg)-based microparticles in aiding the treatment of OA. Mg-based materials are thought to be a suitable biomaterial candidate due to their cytocompatibility, ability to degrade and noteworthy is their osteopromotive quality.

The main objective of this research was to demonstrate the positive link of Mg implant in preventing the occurrence of OA. To achieve the objective this thesis covered a series of experiments right from the degradation of Mg implant in physiological medium to the implant’s compatibility on SCP1 cells. The final part investigated the association of Mg implants in an OA in vitro model revealing the significance of Mg in reducing the progression of OA.

The evidence collected in this thesis leads to the conclusion that Mg-based microparticles have the potential to slow the progression of in vitro OA and help restore the differentiation potential/repair mechanism in bone and cartilage, depending on the severity of the inflammation. The ability of Mg microparticles to safely degrade with minimal toxicity on cells and the capability to support bone/cartilage repair mechanisms in vitro, makes Mg a versatile material for bone and cartilage tissue applications. The degradation rate, cytocompatible characteristics, and the demonstrated support for bone and cartilage repair mechanisms in vitro highlight the potential of Mg microparticles as an intelligent bioimplant material for OA therapy.

Rechte

Nutzung und Vervielfältigung:


CC BY 4.0

Bitte beachten Sie, dass einzelne Bestandteile der Publikation anderweitigen Lizenz- bzw. urheberrechtlichen Bedingungen unterliegen können.

Zitieren

Zitierform:
Zitierform konnte nicht geladen werden.