Reply to: Vitamin C as a promoter of γδ T cells
Last year, we published a paper in this journal in which we described the effects of vitamin C and its phospho-modified version (phospho-vitamin C, pVC) on the in vitro activation, proliferation, and effector function of human γδ T cells. We were delighted to see that our study was recently highlighted in a Comment in this journal by Meraviglia and Dieli, underscoring the potential interest in using vitamin C to promote γδ T cell activity for use in cancer immunotherapy. Our study was a joint publication with our Chinese collaborators, headed by Prof. Zhinan Yin, with whom we share an interest in exploring the beneficial effects of vitamin C on boosting the cellular immune response. In fact, Yin and colleagues initiated clinical studies on the adoptive transfer of allogeneic γδ T cells expanded in the presence of vitamin C into cancer patients. A report of a clinical phase I study demonstrating the safety of allogeneic γδ T cell transfer has recently been published in this journal, another collaborative effort of our two groups
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