Veränderte T-Zell-Reaktion gegen Hefepilze bei chronischer Darmentzündung

Inappropriate CD4+ T cell responses against species of the intestinal microbiome have been suggested to contribute to the chronic inflammation of Crohn’s disease (CD). However, the microbial species that drive such inappropriate CD4+ T cell responses and the pathogenic T cell functions in CD remain largely unknown. Our work provides evidence that aberrant cytotoxic Th 1 cells directed against both commensal and food-derived yeasts may contribute to the inflammatory immune response in patients with CD.

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Published in:
BIOspektrum
Publisher:
Springer Science and Business Media LLC
Spektrum, Akad. Verl.
Elsevier, Spektrum, Akad. Verl.
Spektrum, Akad. Verl.
Publishing place:
Heidelberg
Heidelberg
Heidelberg
Heidelberg
Vol.:
30
No.:
2
ISSN:
0947-0867
ISSN:
1868-6249
ISSN:
0947-0867
Pages:
154 - 157
Date Issued:
2024
URN:
urn:nbn:de:gbv:8:3-2026-01004-6
DOI:
10.1007/s12268-024-2148-3
Language:
English
Type of Resource:
Text
Publisher:
Springer Science and Business Media LLC
Keywords:
Crohn’s disease; Intestinal microbiome; CD4+ T cells; Cytotoxic Th1 cells; Commensal and food-derived yeasts
Classification:
Published version
DDC subject of DNB:
610 Medical sciences, health
Hosting institution:
Affiliated Institutes, University Hospital Schleswig-Holstein (UKSH)

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