Dual-Task Performance in GBA Parkinson’s Disease

Srulijes, Karin; Brockmann, Kathrin; Ogbamicael, Senait; Hobert, Markus A.; Hauser, Ann-Kathrin; Schulte, Claudia; Fritzen, Jasmin; Schwenk, Michael; Gasser, Thomas; Berg, Daniela; Maetzler, Walter ORCID

INTRODUCTION Parkinson's disease patients carrying a heterozygous mutation in the geneglucocerebrosidase(GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients. METHODS Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included. Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck's Depression Inventory). Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit. These parameters corrected for UPDRS and MoCA were then compared between the groups. RESULTS Under the DT condition "walking while checking boxes," GBA-PD patients showed slower gait and box-checking speeds than iPD patients. GBA-PD and iPD patients did not show significant differences regarding dual-task costs. CONCLUSION This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients. This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies.


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Srulijes, Karin / Brockmann, Kathrin / Ogbamicael, Senait / et al: Dual-Task Performance in GBA Parkinson’s Disease. 2017.

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