Wirkstoffkristallisate und proliposomal verkapselte Wirkstoffe aus überkritischer Gasphase
The aim of this study on the one hand was to evaluate the micronisation of budesonide at various process conditions in the ASES-process. Thereby the obtained results show that the varied parameters CO2 flow rate and solution feed rate did hardly influence the micronisation process. On the other hand the feasibility of the micronisation of formoterol with supercritical carbon dioxide in the ASES-process was investigated. For these purposes the process parameters pressure and temperature in the ASES-process were varied as well as the drug solvents. Another aspect of this work was the development of liposomes in a dry reconstitutable form. Also in this case the ASES-process should act as an alternative to the standard liposome preparation methods. For these purposes different compositions consisting of lecithin, cholesterol and budesonide were precipitated under various conditions in supercritical carbon dioxide.