Models of evolutionary rescue of bacteria and yeast by extrachromosomal genetic elements

Many organisms contain extrachromosomal genetic elements, additional components of the genome outside of the main chromosomal component. Mathematical modelling has already made an extensive contribution to the theoretical population genetics of normal, chromosomal genes, but extrachromosomal genetic elements are less well studied. In this thesis, I develop mathematical models of the contribution of two extrachromosomal genetic elements, plasmids in bacteria and eccDNA in yeast, to the evolutionary rescue of their hosts. In both cases, the unique extrachromosomal properties of the genetic system facilitate their contribution to the rapid adaptation of the host to an environmental change.

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Dewan, I.A., 2025. Models of evolutionary rescue of bacteria and yeast by extrachromosomal genetic elements.
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